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Castle Creek Pharmaceutical Holdings Inc. is set to acquire Fibrocell Science Inc., a cell and gene therapy company focused on transformational autologous cell-based therapies for skin and connective tissue diseases.

With the resources of CCP Holdings' subsidiary, Castle Creek Pharmaceuticals LLC, a privately held biopharmaceutical company developing innovative therapies for patients with rare, serious or debilitating dermatologic conditions, Fibrocell's gene therapy platform can be advanced into additional areas of high, unmet need with the potential to develop multiple, promising new therapies.

"Our current licensing and development collaboration with Fibrocell, which began in April 2019, has cemented a shared focus on delivering the first approved therapies for families who are impacted by rare dermatologic conditions like epidermolysis bullosa (EB), a chronic, painful and debilitating disease that leads to severe blistering starting early in life and can only be treated with palliative care including extensive bandaging," said Castle Creek CEO Greg Wujek. "As one company, we will be in a strong position to push forward initially with two late-stage clinical development programs targeting different types of EB with investigational gene and topical therapies, and one potential therapy for scleroderma."

EB is a rare genetic condition that leads to extremely fragile skin resulting in mild to severe blistering, skin erosion and peeling of the epidermis layers in response to minor injury. There are currently no treatment options approved by the U.S. Food & Drug Administration (FDA) for any form of EB.