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Limelight Bio, a privately held, multi-platform, multi-disease biopharmaceutical company developing novel gene therapies, raised $75 million in new financing funded by Apple Tree Partners, a life sciences innovation fund.

Limelight Bio has developed proprietary technologies, advanced targets and leading drug candidates designed to overcome key limitations of current gene therapy and gene editing approaches. Initial areas of focus include severe retinal, hematologic/metabolic, neurologic and hearing loss diseases where no current therapies exist. Limelight Bio is led by CEO Michael Ehlers, MD, PhD, with operations in Philadelphia and Cambridge.

Limelight Bio is building a platform to develop technologies, advanced targets, and leading drug candidates designed to treat more diseases for many more patients. The company is pioneering gene correction across unprecedented areas, including proprietary methods that persistently correct large genetic defects independent of gene size or mutation pattern without risk of permanent genomic alteration. Founders include Jean Bennett, MD, PhD of the University of Pennsylvania Perelman School of Medicine and co-director of the CAROT program, and Phil Johnson, MD, former Chief Scientific Officer of the Children’s Hospital of Philadelphia. Dr. Johnson’s work on vaccines, virology, and gene therapy has been foundational for advancing novel therapeutic approaches. Dr. Bennett’s ground-breaking research led to the development of an FDA-approved and marketed gene therapy product and she is a scientific advisor for Limelight Bio.

“There is great potential for Limelight’s technology to transform gene therapy far beyond where it is today,” said Dr. Bennett. “With these advanced tools and technologies, we now have the means to go straight to the origin of the most complex genetic diseases. It could become the foundation for a new class of medicines.”

“We believe Limelight Bio has the potential to leapfrog the prevailing gene therapy and editing approaches to tackle a much broader array of genetic disorders,” said ATP Managing Partner Seth Harrison, MD. “With Mike Ehlers joining as CEO, we have added fantastic R&D leadership to what looks to us to be break-out technology to create the first gene therapy-based pharmaceutical company.”